Study | Interchangeability between Hard Gelatin and Hard Hypromellose Capsules without gelling agent

FloVitroTM method uses a flow-through approach that utilizes a series of solid transfer cells that incorporate pharmacokinetic characteristics.

Experiments were performed to collect data to define the dissolution behavior of Propranolol HCL (a BCS Class I API) encapsulated into gelatin capsules and HPMC capsules using both a modified USP apparatus II and the FloVitroTM methods, and (2) compare the pharmacokinetic parameters for the gelatin and the HPMC capsules determined from the drug concentration versus time profiles generated by the FloVitroTM method.

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