FDA Approves Amgen’s Heart Failure Drug
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The US Food and Drug Administration (FDA) has approved Amgen’s heart failure drug, Corlanor (ivabradine), an oral medication Corlanor was developed by Les Laboratoires Servier. Through a collaboration with Servier, Amgen has rights to commercialize Corlanor in the US.

Corlanor is approved for use in certain people who have long-lasting (chronic) heart failure caused by the lower-left part of their heart not contracting well. The drug is indicated for patients who have symptoms of heart failure that are stable, a normal heartbeat with a resting heart rate of at least 70 beats per minute, and are also taking beta blockers at the highest dose they can tolerate.

Corlanor blocks the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel responsible for the cardiac pacemaker, which regulates heart rate. Corlanor reduces the spontaneous pacemaker activity of the cardiac sinus node by selectively inhibiting the so-called “funny” current to slow the heart rate with no effect on ventricular repolarization and no effects on myocardial contractility, according to Amgen.

Source: Amgen  and FDA

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