FDA Grants Orphan Drug Status to AstraZeneca’s mAbBy
AstraZeneca and its global biologics research and development arm, MedImmune, report that US Food and Drug Administration (FDA) has granted Orphan Drug Designation for the investigational anti-CD19 monoclonal antibody, MEDI-551, for the treatment of patients with neuromyelitis optica (NMO) as well as neuromyelitis optica spectrum disorders (NMOSD). Developed by MedImmune, MEDI-551 is currently in Phase IIb clinical development for NMO.
NMO is a rare, life-threatening autoimmune disease of the central nervous system in which the body's immune system attacks healthy cells, most commonly in the optic nerves and spinal cord, resulting in severe damage. NMO causes severe muscle weakness and paralysis, loss of vision, respiratory failure, problems with bowel and bladder function and neuropathic pain.1 There is currently no cure or approved medicine for NMO, which affects about five in 100,000 people.
Research has shown that patients with NMO and NMOSD develop antibodies against a protein in their body called aquaporin-4, and these antibodies play a key role in NMO disease pathogenesis. MEDI-551 directly targets and depletes cells that produce these antibodies.
The FDA's Orphan Drug Designation programme provides orphan status to potential medicines intended for the safe and effective treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the US.