FDA OKs BI, Lilly Diabetes Drug
The US Food and Drug Administration (FDA) has approved Glyxambi (empagliflozin/linagliptin) tablets, from Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes (T2D) when both empagliflozin and linagliptin are appropriate treatments.
The drug is part of the companies’ diabetes alliance, which was formed in 2011. Glyxambi has a dual mechanisms of action of a sodium glucose co-transporter-2 (SGLT2) inhibitor and a dipeptidyl peptidase-4 (DPP-4) inhibitor in a once-daily tablet taken in the morning. It combines 10 mg or 25 mg of empagliflozin with 5 mg of linagliptin. SGLT2 inhibitors remove glucose through the urine by blocking blood glucose re-absorption in the kidney. DPP-4 inhibitors work by increasing hormones that stimulate the pancreas to produce more insulin and stimulate the liver to produce less glucose.
Source: Eli Lilly