Hospira Initiates Voluntary Recall of One Lot of Bupivacaine HCl
Hospira, Inc. announced on June 17, 2014, that it will initiate a voluntary nationwide recall to the user level for one lot of 0.5% Marcaine (bupivacaine HCl Injection, USP), 30-mL, single-dose vial â€“preservative free (NDC 0409-1560-29), Lot 33-545-DD. The recall is due to a confirmed customer report of particulate embedded in the glass vial as well as visible particulate in the solution.
To date, Hospira said it has not received reports of any adverse events associated with this issue for this lot. Hospira has attributed the embedded particulate to a supplier's glass defect. Hospira is working with its supplier on implementing corrective and preventive actions. Marcaine is packaged 10 units per carton/100 units per case in glass fliptop vials. The impacted lot of Marcaine was distributed November 2013 through March 2014 to wholesalers/distributors, hospitals and clinics nationwide.
If the particulate goes undetected and solution is administered, depending on the particle size and number ,it could block administration of the drug to the patient, causing a delay in therapy. The company, says, however, this is an unlikely outcome due to the size of the subvisible particulates identified. It is more likely that particulates are able to pass through the catheter and may result in local inflammation, mechanical disruption of tissue or immune response to the particulate. While extremely rare, particulate exposed to strong magnetic fields (e.g. MRI), could potentially dislodge and cause tissue damage; however, the company says the particulate size identified is considered too small., and therefore, an adverse outcome is extremely unlikely.