Lonza, BioWa Form Licensing Agreement with arGEN-X BV

BioWa Inc. and Lonza have entered into a licensing agreement with arGEN-X BV, a clinical-stage human therapeutic antibody company. arGEN-X has licensed the companies' POTELLIGENT® CHOK1SV Cell Line Technology for use in the development of ARGX-110, a proprietary antibody in its pipeline.

POTELLIGENT® CHOK1SV is a host cell line for manufacturing recombinant antibodies that combines the BioWa's engineered glycosylation POTELLIGENT® technology with Lonza's GS Gene Expression System™. The GS System™ includes Lonza's pre-eminent host cell line, CHOK1SV. POTELLIGENT® technology is designed to improve the potency and efficacy of therapeutic antibodies by enhancing antibody-dependent cellular cytotoxicity (ADCC), one of the major mechanisms of therapeutic antibodies.

This agreement follows a licensing agreement between arGEN-X and BioWa, initiated in 2010, to apply BioWa's POTELLIGENT® Technology to therapeutic antibodies discovered by arGEN-X.

ARGX-110 is a monoclonal antibody targeting CD70 positive tumors with three distinct modes of action: potent tumor cell depletion through enhanced ADCC and deprivation of both a key stimulation signal and immune privilege. 

Source: Lonza

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